01 - Whisk together buttermilk and hot sauce in a large bowl. Submerge chicken pieces completely in the mixture. Cover bowl and refrigerate for minimum 1 hour, preferably overnight for optimal flavor penetration.
02 - Combine paprika, garlic powder, onion powder, oregano, thyme, cayenne pepper, black pepper, and salt in a small bowl. Measure and reserve 2 teaspoons of this blend for the breading mixture.
03 - Mix all-purpose flour, cornstarch, and reserved 2 teaspoons Cajun seasoning in a shallow dish until thoroughly combined.
04 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into the flour mixture, ensuring complete coverage on all sides. Shake off excess coating.
05 - Pour vegetable oil to depth of 2 inches in large deep skillet or Dutch oven. Heat to 350°F, monitoring with cooking thermometer.
06 - Cook chicken in small batches to maintain oil temperature. Turn pieces occasionally for even browning. Fry until golden brown and internal temperature reaches 165°F, approximately 12-15 minutes per batch. Avoid overcrowding the pan.
07 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest for 5 minutes before serving to allow juices to redistribute.